苯甲酸钠对植物萌发的影响初探

苯甲酸钠是常用的食品防腐剂，对酵母菌和细菌的繁殖有较强的抑制作用。本文报告苯甲酸钠对大蒜和豌豆这两种植物萌发影响的初步试验，表明一定浓度的苯甲酸钠对植物的萌发有明显的抑制作用。     

生态系统服务簇空间演变轨迹及其社会-生态驱动的地理探测——以大连市为例

生态系统服务簇是多种生态系统服务的组合，明晰生态系统服务簇及其自然-社会经济驱动因素，对生态系统服务内部相互依赖机制识别、实现多种生态系统服务间良性互动具有重要意义。目前生态系统服务簇的识别已得到广泛应用，但对多种生态系统服务之间交互作用的动态过程与影响机理的认识还不够深刻。针对目前多种生态系统服务间交互作用动态演化分析及其社会-生态驱动机理研究不足的现状，以我国北方沿海重要中心城市——大连市为例，选取食物供给、水源涵养、固碳释氧、土壤保持、生境质量和景观美学6种关键服务。采用Spearman相关性分析方法探究生态系统服务权衡与协同关系，借助自组织网络方法识别生态系统服务簇，进一步分析多种生态系统服务间交互作用的时空分异特征，运用地理探测器探究其空间分异影响因素。结果表明：(1)食物供给与土壤保持存在极显著的权衡关系■,土壤保持与景观美学存在极显著的协同关系■。(2)2005—2015年大连市生态保育簇空间格局较稳定，水源涵养簇、食物供给簇与服务枯竭簇之间轨迹变化明显，城市扩张与服务枯竭簇演变具有一致性。(3)高程、归一化植被指数是影响生态系统服务簇空间分布的关键自然因素，而土地利用强...     

okemon及其在肿瘤中的研究进展

Pokemon 基因即POK 红系髓性致癌因子，也被称为FBI -1 ，LRF ，OCZF ，TIP ，它是POK 转录抑制物家族成员之一，其编 码的产物具有BTB / POZ 域和锌指结构,它是第一个被发现的可变阅读框基因ARF ( Alternative reading frame ，ARF )的特异性 转录抑制物，Pokemon 通过特异抑制ARF 转录来调控细胞周期、诱导肿瘤发生、促进肿瘤的发生发展，在一些人类肿瘤如食管鳞 癌、肺癌、结肠癌、人贲门癌、膀胱癌，前列腺癌和乳腺癌等肿瘤组织中具有较高的表达水平。Pokemon 的特殊性在于还能与其它 癌基因如Bcl-2，MDM2 等结合之后发挥作用来促进其他癌基因的活性。因此可以认为Pokemon 是肿瘤的总开关，对Pokemon 基 因的进一步研究有助于为肿瘤的诊断和治疗提供新的途径和方法。     

具有阶段结构和免疫反应的病毒动力学模型的全局稳定性

研究了一类被感染细胞具有潜伏和活性两阶段以及免疫反应的病毒动力学模型.通过建立适当的Lyapunov泛函和使用LaSalle不变集原理,获得当σ≤1,ω≤1σ和σω1时,对应的未感染平衡点P,体液免疫未激活的无免疫感染平衡点M,体液免疫已激活的感染平衡点N是全局渐近稳定的充分条件.所获得结果推广了Nowak(1996)和Bangham(1997)的工作,得到了一些新结果.     

Cross-Sectional Associations between Body Size,Circulating Sex-Steroid Hormones and IGF Components among Healthy Chinese Women

The incidence of breast cancer has increased in Asian countries and rates of hormone receptor (HR) negative breast cancer exceed those of Western countries. Epidemiologic data suggest that the association between body size and BC risk may vary by HR status, and could differ geographically. While body size may influence BC risk by moderating the synthesis and metabolism of circulating sex-steroid hormones, insulin-like growth factor (IGF)-1 and related binding proteins, there is a dearth of literature among Asian women. We aimed to examine these specific associations in a sample of Chinese women. In Sichuan Province 143 women aged ≥40 years were recruited through outpatient services (2011–2012). Questionnaires, anthropometric measurements, and blood samples were utilized for data collection and linear regression was applied in data analyses. Among women <50 years we observed a non-monotonic positive association between body mass index (BMI) and 17β-estradiol, and a reversed J-shaped association between BMI and IGF-1 (p ≤0.05). We observed similar associations between waist-to-hip ratio and these markers. Our finding of augmented IGF-1 among women with low body mass may have implications for understanding breast tumor heterogeneity in diverse populations and should be evaluated in larger prospective studies with cancer outcomes.     

Physiological functions of Wilms’ tumor 1-associating protein and its role in tumourigenesis

The Wilms’ tumor-associated gene WT1 encodes a tumor suppressor gene, which is implicated in renal differentiation and development of adult urogenital system. Wilms’ tumor 1-associating protein (WTAP) is initially identified as a nuclear protein that specifically interacts with WT1 in both in vitro and in vivo assays. WTAP is ubiquitously expressed in different tissues and various growth periods, and its expression is involved in cell cycle, RNA splicing and stabilization, N6-methyladenosine RNA modification, cell proliferation, and apoptosis as well as embryonic development. In the present review, we aimed to summarize the functions of WTAP in various physiological and pathological processes, in particular with regard to the current knowledge about the role of WTAP in tumorigenesis of different cancers.     

Deep-lipidotyping by mass spectrometry: recent technical advances and applications

In-depth structural characterization of lipids is an essential component of lipidomics. There has been a rapid expansion of mass spectrometry methods that are capable of resolving lipid isomers at various structural levels over the past decade. These developments finally make deep-lipidotyping possible, which provides new means to study lipid metabolism and discover new lipid biomarkers. In this review, we discuss recent advancements in tandem mass spectrometry (MS/MS) methods for identification of complex lipids beyond the species (known headgroup information) and molecular species (known chain composition) levels. These include identification at the levels of carbon-carbon double bond (C=C) location and sn-position, as well as characterization of acyl chain modifications. We also discuss the integration of isomer-resolving MS/MS methods with different lipid analysis workflows and their applications in lipidomics. The results showcase the distinct capabilities of deep-lipidotyping in untangling the metabolism of individual isomers and sensitive phenotyping by using relative fractional quantitation of the isomers.     

Multiple species of wild tree peonies gave rise to the ‘king of flowers’, Paeonia suffruticosa Andrews

The origin of cultivated tree peonies, known as the ‘king of flowers'' in China for more than 1000 years, has attracted considerable interest, but remained unsolved. Here, we conducted phylogenetic analyses of explicitly sampled traditional cultivars of tree peonies and all wild species from the shrubby section Moutan of the genus Paeonia based on sequences of 14 fast-evolved chloroplast regions and 25 presumably single-copy nuclear markers identified from RNA-seq data. The phylogeny of the wild species inferred from the nuclear markers was fully resolved and largely congruent with morphology and classification. The incongruence between the nuclear and chloroplast trees suggested that there had been gene flow between the wild species. The comparison of nuclear and chloroplast phylogenies including cultivars showed that the cultivated tree peonies originated from homoploid hybridization among five wild species. Since the origin, thousands of cultivated varieties have spread worldwide, whereas four parental species are currently endangered or on the verge of extinction. The documentation of extensive homoploid hybridization involved in tree peony domestication provides new insights into the mechanisms underlying the origins of garden ornamentals and the way of preserving natural genetic resources through domestication.